Tic-TACs: Refreshing Hair Growth
نویسندگان
چکیده
Although stem cells are subject to niche control, evidence is emerging that they also contribute to generating the niche through their offspring. Using the hair follicle as a model, Hsu at al. demonstrate that the transient-amplifying cells, downstream of stem cells and well-known cell producers, signal back to stem cells to maintain long-term regenerative capacity.
منابع مشابه
Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
Transit-amplifying cells (TACs) are an early intermediate in tissue regeneration. Here, using hair follicles (HFs) as a paradigm, we show that emerging TACs constitute a signaling center that orchestrates tissue growth. Whereas primed stem cells (SCs) generate TACs, quiescent SCs only proliferate after TACs form and begin expressing Sonic Hedgehog (SHH). TAC generation is independent of autocri...
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عنوان ژورنال:
- Cell
دوره 157 شماره
صفحات -
تاریخ انتشار 2014